miR-9 and NFATc3 Regulate Myocardin in Cardiac Hypertrophy
نویسندگان
چکیده
منابع مشابه
miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy.
Cardiac hypertrophy is accompanied by maladaptive cardiac remodeling, which leads to heart failure or sudden death. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that mediate posttranscriptional gene silencing. Recent studies show that miRNAs are involved in the pathogenesis of hypertrophy, but their signaling regulations remain to be understood. Here, we report that miR-23a is a pro-...
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MicroRNAs (miRNAs), small non-coding RNA molecules, are derived from intergenic, intronic, or exonic regions in the genome and are transcribed by RNA polymerases into primary transcripts (pri-miRNAs) as single genes or clusters. Pri-miRNAs, which contain stem-loop structures harbouring the miRNAs in the 5′ or 3′ half of the stem, are recognized by the endonuclease Drosha in the nucleus to produ...
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RATIONALE In Drosophila, the Hippo signaling pathway negatively regulates organ size by suppressing cell proliferation and survival through the inhibition of Yorkie, a transcriptional cofactor. Yes-associated protein (YAP), the mammalian homolog of Yorkie, promotes cardiomyocyte growth and survival in postnatal hearts. However, the underlying mechanism responsible for the beneficial effect of Y...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.098004